Removing crayon stains from clothes requires a multi-pronged approach. Spot cleaning with a solvent like rubbing alcohol or hairspray can work for fresh stains. For set-in stains, soaking in a detergent solution or using enzymatic stain removers can break down the wax. Additionally, heat treatment with an iron or hair dryer can help melt the wax, making it easier to remove. Always test cleaning methods on an inconspicuous area first and use caution, as harsh chemicals or excessive heat can damage certain fabrics.