Skin barrier integrity is maintained through a delicate balance of lipids (ceramides, fatty acids, cholesterol), humectants (hyaluronic acid), and peptides. Lifestyle modifications like avoiding harsh soaps, using lukewarm water, and limiting sun exposure can help. Medical conditions like eczema and psoriasis can disrupt the barrier, requiring prescription treatments and ceramides supplements. A tailored skincare regimen, including cleansing, moisturizing, and protecting, can restore and strengthen the skin barrier. Seeking professional advice for persistent dryness is recommended.